Projects

Research Associate
Ing. Helena Kavcová

International

Finished
  • P-glycoproteín Mediated Multidrug Resistance in Radiation-Associated Hematological Malignancies Following the Chernobil Accident.
    Program: NATO
    Duration: 1. 1. 2007 – 31. 12. 2008

National

Current
  • The effect of UV-B radiation on DNA damage and repair mechanisms in the P-glycoprotein-expressing L1210 cell line
    Program: VEGA
    Duration: 1. 1. 2022 – 31. 12. 2025
  • A new insight at isothiocyanates as substances interfering with the homeostasis of neoplastically transformed cells
    Program: VEGA
    Duration: 1. 1. 2021 – 31. 12. 2024
  • Defense mechanisms of microbial and animal cells in reducing their sensitivity to plant defensive compounds
    Program: SRDA
    Duration: 1. 7. 2020 – 30. 6. 2024
  • Multidrug resistance of leukemia cells - Phenotype caused by interference of multimodal molecular reasons
    Program: SRDA
    Duration: 1. 7. 2020 – 30. 6. 2024
Finished
  • Study of alteration in leukemia cells phenotype after induction of ABCB1 membrane transporter
    Program: VEGA
    Duration: 1. 1. 2019 – 31. 12. 2022
  • Effect of endoplasmic reticulum-stress inducing substances on cell cycle regulatory mechanisms in cell lines with MDR phenotype
    Program: VEGA
    Duration: 1. 1. 2019 – 31. 12. 2021
  • The effect of polyphenols on the functions of signal proteins involved in proteins N-glycosylation in the endoplasmic reticulum of leukemia cells, depending on the expression of P-glycoprotein
    Program: VEGA
    Duration: 1. 1. 2018 – 31. 12. 2021
  • The effect of endoplasmic reticulum stress inductors and proteaosome inhibitors on leukemia cell line L1210, SKM-1 and MOLM-13 with induced P-glycoprotein overexpression
    Program: VEGA
    Duration: 1. 1. 2016 – 31. 12. 2018
  • Changes of leukemia cells drug sensitivity induced by changes of membrane drug transporters expression profile.
    Program: VEGA
    Duration: 1. 1. 2015 – 31. 12. 2018
  • Effect of overexpression of P-glycoprotein and development of multidrug resistance on some aspects of metabolism
    Program: VEGA
    Duration: 1. 1. 2010 – 31. 12. 2012
  • Changes of neoplastic cell metabolism associated with development of p-glycoprotein mediated miltidrug resistance induced by adaptation of sensitive cells to drugs
    Program: VEGA
    Duration: 1. 1. 2007 – 31. 12. 2009
  • Phenotype of multidrug resistance associated with overexpresion of mdr 1 - p-glycoprotein in neoplastic cells
    Program: VEGA
    Duration: 1. 1. 2006 – 1. 12. 2008
  • Calcium homeostasis and signalization in cells - structural, functional and metabolic relations during developmentof patologic changers
    Program: SRDA
    Duration: 1. 1. 2005 – 1. 12. 2007
Employees