Dept. of Biochemistry of Biomembranes
Department consists of three laboratories: Laboratory of Membrane Biogenesis, Laboratory of Cell Cycle and Laboratory of Biosensors.
Laboratory of Membrane Biogenesis
The main interest of the laboratory is to study processes by which eukaryotic cells regulate lipid composition of their membranes. We are aimed to understand the mechanisms of action of anti-sterol antimycotics and especially the mechanisms of resistance towards these drugs. In the yeasts Saccharomyces cerevisiae and Schizosaccharomyces pombe as model eukaryotic organisms we study how defects in lipid metabolism lead to disturbance of cellular functions involved in development of serious human diseases. Important part of our research is oriented towards production of valuable lipid compounds in yeast.
Laboratory of Cell Cycle
The Laboratory of Cell Cycle focuses on the study of chromosomal segregation during meiosis using the yeast Schizosaccharomyces pombe as a model eukaryotic organism. We are particularly interested in proteins involved in homologous recombination and karyogamy. By studying these proteins we seek to discover how their dysfunction can lead to various diseases such as Down Syndrom or cancer in humans. More information about Laboratory of cell cycle.
Development of novel biosensors as a tool for early detection of cancer is in the focus of our research. We use DNA aptamers, unique detection elements that bind the target molecules with high affinity and selectivity. Use of golden nanoparticles attached to the aptamers multiplies the signal and enables detection of cancer cells in early stages of the disease. The selectivity of aptamers to surface receptors of cancer cells is tested using acoustic TSM technology and by state-of-the-art single molecule force spectroscopy.